OverviewOptimizer needs to be restarted after making any changes in the optimizer i-e in Circuit, VC"s or policies. Also any changes like change in application group, network object etc that are used in VC's or policies needs optimizer to be restarted. Unless optimizer is restarted new changes will not come into affect.
Web UI: After making changes optimizer can be restarted via drop down menu on the dashboard beside optimizer (usually it prompts to restart if it detects any changes).
Cli: Follow steps from here http://goexinda.force.com/support/articles/support_article/Start-Stop-Optimizer-via-CLI